Detection Period: 2-4 days after use
Detection Level: 10 ng/mL (with Buprenorphine as the calibrator*)
Brief Description of Drug: Buprenorphine is a pain reliever and is used for opioid dependence management. It provides relief from pain and euphoria while helping manage opioid withdrawal symptoms.
Typically Prescribed For:
- Opioid addiction treatment
Effects:
- Relief from pain
- Euphoria
- Respiratory depression
Forms: Tablets and film
Methods of Consumption: Swallowed
Buprenorphine is prescribed at low doses as an addiction therapy drug or substitute for an abused drug, like heroin. Buprenorphine has enough of an opiate effect to help the dependent individual give up heroin without experiencing the full withdrawal symptoms.
Buprenorphine is a member of the opioid class of drugs and is made from thebaine, a natural compound found in opium poppy juice.
Similar in purpose to methadone, buprenorphine (also known by its trade names of Suboxone, Subutex, and Temgesic) is most commonly seen as an addiction management aid. As Wired Magazine puts it, buprenorphine "pushes the same buttons as heroin or painkillers like Vicodin, Percocet, or OxyContin, only without the high or any other significant side effects." Both methadone and buprenorphine are used to help patients detox, but buprenorphine is longer-lasting, not necessarily requiring a daily dose. Buprenorphine is seen as less addictive than methadone and easier to withdraw from.
Suboxone is more commonly prescribed than Subutex (and in fact, both of those and Temgesic are all made by the same company, Reckitt Benckiser, formerly Reckitt & Colman). Suboxone includes naloxone to deter abuse by injection.
*The Buprenorphine urine drug test uses Buprenorphine as the calibrator for the stated 10 ng/mL testing level. The following table lists the concentrations of compounds (ng/mL) that are detected as positive in this urine drug test:
Compound | Detection Level (ng/mL) |
Buprenorphine | 10 ng/mL |
Norbuprenorphine | 20 ng/mL |
Buprenorphine 3-D-glucuronide | 15 ng/mL |
Norbuprenorphine 3-D-glucuronide | 200 ng/mL |
DIRECTIONS FOR USE
Allow the test card and/or test strip, urine specimen, and/or controls to reach room temperature (15-30 degrees Celsios) prior to testing.
DIRECTIONS FOR SINGLE TEST CARD
- Bring the pouch to room temperature before opening it. Remove the test card from the sealed pouch and use it as soon as possible.
- Remove the cap.
- With the arrow pointing toward the urine specimen, immerse the test card vertically in the urine specimen for at least 10 to 15 seconds. Immerse the strip to at least the level of the wavy lines, but not above the arrow on the test card. Replace the cap and place the test card on a non-absorbent flat surface.
- Start the timer and wait for the colored line(s) to appear.
- The result should be read at 5 minutes. Results may be stable up to 1 hour after test initiation.
INTERPRETATION OF RESULTS
NEGATIVE:* Two lines appear. One colored line should be in the control region (C), and another apparent colored line should be in the test region(T). This negative result indicates that the marijuana concentration is below the detectable level (50 ng/mL).
*NOTE: The shade of color in the test line region (T) will vary, but it should be considered negative whenever there is even a faint line.
POSITIVE: One colored line appears in the control region (C). No line appears in the test region (T). This positive result indicates that the marijuana concentration exceeds the detectable level (50 ng/mL).
INVALID: Control line fails to appear. Insufficient specimen volume or incorrect procedural techniques are the most likely reasons for control line failure. Review the procedure and repeat the test using a new test card or test strip. If the problem persists, discontinue use of the lot immediately and contact your distributor.
What drugs will show up on this test?
Answer: Drugs that contain buprenorphine will show up on this test. Among the most popular brands are Suboxone, Subutex, and Temgesic. These drugs are used to help those addicted to opiates/opioids, such as heroin, kick the habit. Buprenorphine-based drugs are used instead of methadone for this purpose with increasing frequency.
Will oxycodone show up as positive on this test?
Answer: No, oxycodone will NOT show up as positive on this test. There are no drugs that cross-react with this test. It only picks up buprenorphine-based drugs (again, like Suboxone, Subutex, and Temgesic).
Will methadone show up on a suboxone / buprenorphine drug test?
Answer: No, methadone will NOT show up as positive on this test. The only drugs that will show up as positive on this test include buprenorphine. Methadone does not include buprenorphine.
Will suboxone / buprenorphine show up on other screens?
Answer: Buprenorphine based drugs like suboxone will not show up as positive on other screens. If someone has buprenorphine and buprenorphine alone in their system they will not show as positive for Opiates, Oxycodone, or Methadone. Buprenorphine will not interfere with those tests.
What is the significance of using Buprenorphine as the calibrator in drug testing?
Answer: Using Buprenorphine as the calibrator means that the test is specifically designed to detect buprenorphine at a cutoff level of 10 ng/mL. This ensures that the test is sensitive to the presence of buprenorphine and its metabolites, providing accurate results for recent use.
Can prescription medications cause a positive drug test for buprenorphine?
Answer: Yes, prescription medications containing buprenorphine can cause a positive drug test. It is important to inform the testing administrator about any prescription medications you are taking and provide documentation from your healthcare provider. This will help differentiate between legitimate medical use and illicit use.
How effective are instant home drug tests for detecting buprenorphine?
Answer: Instant home drug tests for buprenorphine are highly convenient and provide quick results, often within minutes. They are designed to be user-friendly, making them accessible for anyone to administer. When used correctly, these tests offer accurate detection of buprenorphine use, helping to identify recent drug use efficiently. While laboratory-based tests are more comprehensive, home tests are a reliable first step in screening and can be followed up with lab confirmation if needed. The combination of convenience, speed, and accuracy makes instant home drug tests a valuable tool for families, small businesses, and schools looking to maintain a drug-free environment.
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